Ariel E Feldstein Selected Research

Fatty Liver

1/2022	Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis.
1/2020	A Low ω-6 to ω-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth.
1/2019	NAFLD in children: new genes, new diagnostic modalities and new drugs.
1/2017	NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.
12/2016	Fatty liver in adolescents: Mechanisms, clinical features and therapy.
2/2016	Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis.
2/2015	Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis.
10/2014	NLRP3 inflammasome activation is required for fibrosis development in NAFLD.
6/2014	Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model.
2/2014	Obesity, nutrition, and liver disease in children.

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Ariel E Feldstein Research Topics

Disease

67	Non-alcoholic Fatty Liver Disease 01/2022 - 09/2005
45	Inflammation (Inflammations) 01/2022 - 08/2003
34	Fibrosis (Cirrhosis) 01/2022 - 08/2003
24	Fatty Liver 01/2022 - 09/2005
18	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 09/2010
15	Insulin Resistance 01/2022 - 04/2008
12	Liver Diseases (Liver Disease) 01/2022 - 08/2003
9	Obesity 01/2015 - 09/2009
8	Alcoholic Fatty Liver 10/2021 - 05/2012
6	Body Weight (Weight, Body) 01/2022 - 01/2010
6	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2021 - 09/2008
5	Weight Loss (Weight Reduction) 01/2022 - 10/2005
5	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2020 - 04/2016
5	Disease Progression 01/2018 - 04/2008
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2018 - 09/2005
2	Alcoholic Hepatitis 01/2020 - 08/2003
2	Portal Hypertension 01/2018 - 08/2009
2	Neoplasms (Cancer) 01/2017 - 06/2014
2	Pathologic Neovascularization 02/2016 - 10/2013
2	Type 2 Diabetes Mellitus (MODY) 12/2015 - 01/2014
2	Pulmonary Arterial Hypertension 01/2014 - 04/2012
2	Hypertrophy 07/2013 - 09/2012
2	Infections 12/2009 - 04/2003
1	End Stage Liver Disease 01/2022
1	Rupture 01/2022
1	Sclerosing Cholangitis 01/2022

Drug/Important Bio-Agent (IBA)

23	Biomarkers (Surrogate Marker)IBA 08/2020 - 07/2006
19	LipidsIBA 01/2020 - 09/2005
17	InflammasomesIBA 01/2022 - 03/2014
16	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2012
12	CytokinesIBA 01/2022 - 04/2008
10	nasIBA 01/2019 - 10/2009
8	CaspasesIBA 01/2022 - 08/2003
8	Choline (Choline Chloride)IBA 01/2022 - 02/2009
8	Linoleic Acid (Linoleate)IBA 01/2020 - 10/2010
8	Messenger RNA (mRNA)IBA 01/2019 - 09/2010
7	Ethanol (Ethyl Alcohol)IBA 01/2018 - 07/2010
6	Keratin-18 (Keratin 18)IBA 12/2015 - 11/2008
5	Insulin (Novolin)FDA Link 01/2022 - 10/2005
5	MicroRNAs (MicroRNA)IBA 01/2022 - 01/2014
5	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 09/2010
5	Triglycerides (Triacylglycerol)IBA 01/2020 - 02/2009
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018 - 09/2009
5	AntioxidantsIBA 07/2013 - 10/2005
4	NLR ProteinsIBA 01/2022 - 01/2017
4	Alanine Transaminase (SGPT)IBA 01/2020 - 09/2009
4	Pharmaceutical PreparationsIBA 12/2019 - 03/2014
4	Cathepsin BIBA 01/2019 - 05/2008
4	Transaminases (Aminotransferases)IBA 01/2019 - 06/2014
4	Interleukin-6 (Interleukin 6)IBA 01/2017 - 06/2008
4	Fatty Acids (Saturated Fatty Acids)IBA 01/2017 - 09/2012
4	Methionine (L-Methionine)FDA Link 01/2017 - 02/2009
4	AdipokinesIBA 12/2014 - 05/2009
3	LipopolysaccharidesIBA 01/2022 - 01/2020
3	ChemokinesIBA 01/2022 - 01/2014
3	Amino Acids FDA Link 01/2022 - 01/2014
3	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2022 - 01/2014
3	FructoseIBA 12/2021 - 09/2010
3	CholesterolIBA 12/2021 - 09/2010
3	Caspase 1 (ICE Protease)IBA 08/2020 - 10/2014
3	CDAA (Randox)IBA 01/2017 - 01/2014
3	Complement System Proteins (Complement)IBA 04/2016 - 10/2011
3	Caspase 3 (Caspase-3)IBA 03/2016 - 10/2013
3	Aspartate Aminotransferases (Aspartate Transaminase)IBA 06/2015 - 10/2009
3	CollagenIBA 03/2014 - 09/2010
3	LeptinIBA 01/2014 - 09/2009
2	Tamoxifen FDA LinkGeneric 01/2022 - 10/2014
2	Adenosine Triphosphate (ATP)IBA 01/2022 - 01/2018
2	AntibodiesIBA 12/2021 - 10/2010
2	Biological ProductsIBA 01/2020 - 02/2019
2	Interleukin-17 (Interleukin 17)IBA 01/2020 - 01/2018
2	EnzymesIBA 01/2019 - 10/2017
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 09/2005
2	wisteria lectinIBA 01/2018 - 01/2018
2	Betaine (C.B.B.)FDA Link 01/2018 - 04/2011
2	Mitochondrial DNA (mtDNA)IBA 01/2018 - 01/2016
2	Dietary Fats (Dietary Fat)IBA 01/2018 - 10/2017
2	Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)IBA 10/2017 - 01/2014
2	Phospholipids (Phosphatides)FDA LinkGeneric 06/2014 - 07/2010
2	Phosphatidylcholines (Phosphatidylcholine)IBA 06/2014 - 04/2011
2	Omega-6 Fatty Acids (Omega 6 Fatty Acids)IBA 01/2014 - 11/2013
2	AcidsIBA 11/2013 - 07/2010
2	BilirubinIBA 07/2013 - 10/2010
2	fibroblast growth factor 21IBA 07/2013 - 11/2010
2	AdiponectinIBA 01/2013 - 09/2009
2	Pentoxifylline (Trental)FDA LinkGeneric 10/2012 - 11/2011
2	Transforming Growth Factors (Transforming Growth Factor)IBA 05/2012 - 09/2010
2	Death Domain ReceptorsIBA 06/2011 - 11/2003
2	Retinol-Binding Proteins (Retinoid Binding Proteins)IBA 11/2009 - 05/2009
1	InterleukinsIBA 01/2022
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022
1	AntigensIBA 12/2021
1	Chemokine ReceptorsIBA 12/2021
1	lipoarabinomannan (LAM)IBA 12/2021
1	Bile Acids and Salts (Bile Acids)IBA 10/2021
1	phosphatidylcholine-ceramide phosphocholine transferaseIBA 10/2021

Therapy/Procedure

17	Therapeutics 11/2021 - 07/2003
7	Liver Transplantation 02/2021 - 04/2003
3	Ligation 11/2019 - 01/2017
2	Bariatric Surgery 02/2021 - 11/2008